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Home » Products » Anticancer Injectables » Bleomycin Injection

Bleomycin Injection

Bleomycin Injection
Bleomycin Injection
Product Code : 03
Product Description
Having immense expertise in this domain, we have been engrossed in providing quality checked Bleomycin Injection. This injection is processed using high grade chemicals by our adroit professionals with the aid of pioneering methodology. The provided injection is used for treating the cancer by stopping the growth of cancer cells. Furthermore, the offered Bleomycin Injection can be purchased at market leading prices from us in various packaging options.
Key Points:

  • Anti-neoplastic
  • Soluble in water  
  • Inhibits DNA synthesis
  • Safe to consume 

 

Bleomycin Injection

Category: anti-neoplastic
Each vial contains:-
Bleomycin sulphate 15 units, 30 units
Bleomycin sulfate for injection is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of streptomyces verticillus. It is freely soluble in water. Between 4. 5 to 6. 0


Pharmacological Action :

Bleomycin is a mixture of cytotoxic glycopeptide antibiotics. It inhibits DNA synthesis. When administered intrapleurally, bleomycin acts as a sclerosing agent.

Precautions:

It is recommended that Bleomycin be administered under the supervision of a qualified health care provider experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available. Before using Bleomycin Sulfate for injection medication, tell your doctor or pharmacist your medical history, especially: immune system problems (e.g., chemotherapy, bone marrow problems), kidney disease, liver disease, lung problems.

Indications:

Bleomycin Sulfate Injection should be considered a Palliative Treatment. It has been shown to be useful in the management of the following neoplasms either as a single agent or in proven combinations with other approved
chemotherapeutic agents: Squamous Cell Carcinoma in Head and neck including mouth, tongue, tonsil, Nasopharynx, Oropharynx, Sinus, palate, Lip, Buccal Mucosa, Gingivae , Epiglottis, skin, Larynx, Cervix, and Vulva. Lymphomas, Testicular Carcinoma, Malignant Pleural Effusion.

Contraindications :

Bleomycin Sulfate injection is contraindicated in patients who have demonstrated a hypersensitive or an idiosyncratic reaction to it.

Adverse Effects :

Pneumonitis progressing to pulmonary anaphylactoid reactions, erythema, rash, striae, vesiculation, hyperpigmentation, rarely myocardial infarction, cerebrovascular accident, haemolytic uraemia syndrome, cerebral arthritis.
Local reactions : Pain, pruritus, hyperpigmentation, scarring, suppuration scaling.

Dosage :

Bleomycin Sulfate injection may be given by the Intramuscular, intravenous, subcutaneous, or Intrapleural routes. Squamous cell carcinoma, non-Hodgkin's lymphoma, testicular carcinoma- 0.25 to 0.50 units/kg (10 to 20 units/m) given intravenously, intramuscularly, or subcutaneously weekly or twice weekly.
Hodgkin's disease :- 0.25 to 0.50 units/kg (10 to 20 units/m) given intravenously, intramuscularly, or subcutaneously weekly or twice weekly.
Note: When Bleomycin sulfate injection is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses.
Malignant Pleural Effusion - 60 units administered as a single dose Bolus Intrapleural Injection.
Intramuscular or Subcutaneous: Bleomycin Sulfate injection 15 units vial should be reconstituted with 1 to 5 ml of Sterile Water for Injection, Sodium Chloride for Injection 0.9% or Sterile Bacteriostatic Water for Injection. Bleomycin Sulfate injection 30 units vial should be reconstituted with 2 to 10 ml of the above diluents.
Intravenous: The contents of the 15 units or 30 units vial should be dissolved in 5 ml or 10 ml, respectively, of Sodium Chloride for Injection, 0.9% and administered slowly over a period of 10 minutes.

Storage :

2-8oC


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