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Home » Products » Anticancer Injectables » Cytarabine Injection

Cytarabine Injection

Cytarabine Injection
Cytarabine Injection
Product Code : 04
Product Description

To fullfill the demand of our valuable clients, we have been betrothed in providing top notch grade Cytarabine Injection. This injection can be bought at reasonable rates from us in safe packaging. At well equipped processing unit, the offered injection is processed using quality checked chemicals by our diligent professionals with the aid of sophisticated methodology. Used to treat cancer, the provided Cytarabine Injection prevents the growth of cancer cells.

Key Points:

  • Antineoplastic and immuno modulating agent
  • No  side effect
  • Fast results
  • Highly effective

 

Cytarabine Injection

It is an amino pyrimidine. It acts mainly in the S-phase of cell cycle when cell is undergoing DNA synthesis. It acts by inhibition of DNA polymerase.

Composition:

Each vai l contains:
Cytarabine: 100mg ,500mg ,1000mg.
Water for injection: qs.


Indications:

Acute non-lymphocytic leukemia of adult and paediatric patients, acute lymphocytic leukaemia chronic myelogenous leukaemia (Blast - phase), meningeal leukaemia (intra - thecal administrations)


Contraindications:

Pharmacological action:

It is an antineoplastic and immuno modulating agent. It is an amino pyrimidine. It acts mainly in the s-phase of cell cycle when cell is undergoing DNA synthesis. It acts by inhibition of DNA polymerase

Adverse Effects:

Bone marow depression which is dose and schedule dependent, nausea, vomiting, diarrhoea, abdominal pain, oral ulceration, hepatic dysfunction infections, paraplegia and necrotising ieukoencephalopathy occurs after intrathecal administration.
Cytarabine syndrome usually occurs 6-12 hours following drug administration. Its characterized by fever, myalgia, bone pain, maculopapular rash, conjunctivitis and malaise. It is treated with steroids.


Dosage:

Drug interaction:

The physician should be alert for possible combined drug actions, desirable or undesirable, involving cyclophosphamide even though cyclophosphamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride.
Since cyclophosphamide has been reported to be more toxic in adrenalectomized dogs, adjustment of the doses of both replacement steroids and cyclophosphamide may be necessary for the adrenalectomized patient..

Precautions:

Special attention to the possible development of toxicity should be exercised in patients being treated with cyclophosphamide if any of the following conditions are present.
Leukopenia
Thrombocytopenia
Tumor cell infiltration of bone marrow
Previous X-ray therapy
Previous therapy with other cytotoxic agents
During treatment, the patient's hematologic profile (particularly neutrophils and platelets) should be monitored regularly to determine the degree of hematopoietic suppression. Urine should also be examined regularly for red cells which may precede hemorrhagic cystitis.



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