|Home||» Products||» Anticancer Injectables||» Etoposide Injection|
As the notable manufacturer, exporter and supplier, our company is betrothed to offer quality tested Etoposide Injection. This injection is processed using top notch grade chemicals and sophisticated methodology under the supervision of our deft professional. The offered injection is used for the preventing the growth of cancer cells and treat lunge cancer. Apart from this, the provided Etoposide Injection can be purchased from us at cost effective rates.
|Composition :||: Each ml contains:
|Indication :|| Small cell lung cancer. Malignant lymphomas. Acute leukaemias, Testicular tumours. Bladder cancer & trophoblastic diseases.
|Dosage :-||In small cell lung cancer, the recommended dose of Etoposide Capsules is two times the IV dose rounded to the nearest 50 mg (i.e., two times 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days). Chemotherapy courses are repeated at 3- to 4-week intervals after adequate recovery from any toxicity.|
|Contra Indications :-||Hypersensitivity, severe liver dysfunction.|
|Special Precautions :-||Renal disease, infections, avoid contact with the skin, mucosa and eye and should not be used in pregnancy, nursing mother and elderly.|
|Pharmacological action:||Etoposide has been shown to cause metaphase arrest in chick fibroblasts. Its main effect, however, appears to be at the G2 portion of the cell cycle in mammalian cells. Two different dose-dependent responses are seen. At high concentrations (10 ÃÂµg/mL or more), lysis of cells entering mitosis is observed. At low concentrations (0.3-10 ÃÂµg/mL), cells are inhibited from entering prophase. It does not interfere with microtubular assembly. The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA topoisomerase II or the formation of free radicals.|
|Pregnancy :-||Should not be used..|
|Lactation :-||Should not be used.|
|Elderly :-||Should not be used.|
|Adverse effect: -||: Myelosuppression, nausea and vomiting, Anaphylactic-like reactions characterized by chills, fever, tachycardia, bronchospasm, dyspnea, and hypotension, Rash, urticaria, and/or pruritus, Alopecia, abdominal pain, aftertaste, constipation, dysphagia, asthenia, fatigue, malaise, somnolence, transient cortical blindness, optic neuritis, interstitial pneumonitis/pulmonary fibrosis, fever, seizure (occasionally associated with allergic reactions), Stevens-Johnson syndrome, and toxic epidermal necrolysis, pigmentation. .|
|Storage: -|| Etoposide Capsules must be stored under refrigeration 2ÃÂ° - 8ÃÂ° C (36ÃÂ° - 46ÃÂ° F). The capsules are stable for 24 months under such refrigeration conditions.
|Drug Interactions :-||Synergism with other cytotoxic drugs.|
|Purity :||Not less than 99%.|