Gentamicin Injection

Composition :

20mg/2ml, 40mg/1ml, 80mg/2ml, 400mg/10ml,1200mg/30ml

Gentamicin:

Potent antibiotic having a broader spectrum of action against a wide variety of bacterial infections.

Indications :

Valuable in critically ill patients, with impaired host defence, burns, urinary tract infections, lung abscesses, osteomyelitis, middle ear infection, septicaemia, meningitis caused by gram negative bacilli.

Dosage :

3-5 mg/kg body wt IM or IV daily in 3 divided doses for 7 to 10 days, 25-50 mg/kg/day

Contra-Indications:

25-50 mg/kg/day.

Contra-indications :-

Uraemia, severe renal function impairment; pregnancy, neonatals (except in life threatening situations)

Special Precautions:

Dose of gentamicin must be precisely calculated according to body wt and level of renal function.

Paediatrics :

Reduced dose necessary.

Elderty:

Reduced dose may be necessary due to adverse effects.

Side Effects:

Irreversible ototoxicity, nephrotoxicity headache, rashes, thrombocytopenia and joint pain.

Drug Interactions :

Increased incidence of toxicity when combined with ethacrynic acid, risk of loss of hearing/kidney failure. Cephalosporins, hydrocortisone & indomethacin potentiate nephrotoxicity, neuro-muscular blocking agents.

Purity :

Not less than 99%.