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Home » Products » Anticancer Injectables » Irinotecan Injection

Irinotecan Injection

Irinotecan Injection
Irinotecan Injection
Product Code : 11
Product Description

Since our inception, we have been affianced in providing the finest grade Irinotecan Injection. This injection is formulated using quality assured chemicals at modern processing unit by a team of adept professionals. The offered injection is used for the treatment of  colon or rectal cancer. This injection works by stopping the growth of cancer cells. In addition to this, the provided Irinotecan Injection can be purchased from us at market leading prices.

Key Points:

  • Longer shelf life
  • Safe and reliable
  • Free from toxic element
  • Accurate composition


 

 

Irinotecan Injection

Category: Anticancer
Each vial contains:-
Each vial contains: Irinotecan 40mg/2ml, 100mg/5ml

Specifications
Irinotecan injection is supplied as a sterile, pale yellow, clear, aqueous solution. The pH of the solution is in between 3.0 to 3.8.


Composition :

Each vial contains:
Irinotecan 40mg/2ml, 100mg/5ml Water for Injection q.s.

Indications :

It is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum.
It is also indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.

Contraindications :

It is contraindicated in patients with a known hypersensitivity to the drug or its excipients.

Pharmacological action:

Irinotecan is a derivative of camptothecin. It interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks.

Adverse Effects :

: Abdominal discomfort, diarrhoea, Leukopenia, neutropenia, haemorrhage, body pain, insomania, dizziness, anaemia vomiting, nausea

Dosage :

Irinotecam should be administered as an intravenous infusion over 90 minutes for both the weekly and once-every-3-week dosage schedules.
Weekly dose schedule: The usual starting dose is 125 mg/m2. Subsequent doses may be adjusted to as high as 150 mg/m2.
Once every three week schedule: starting dose is 350 mg.m2

Storage:

2-80C

Purity :

Not less than 99%.



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