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We come up in the market with an objective to cater diverse needs of clients by offering the best quality Oxaliplatin Injection. The provided product is injected into patients body who are suffering from colon and rectal cancer. Under the stringent observation of dexterous professionals, this injection is formulated with the use of sophisticated methodology. Prior to packaging procedure, the offered Oxaliplatin Injection is rigorously checked on quality parameters to ensure its high effectiveness.
Each vial contains:- Oxaliplatinâ¦.. 2 mg per ml
Pack Size:-25ml , 50 ml
Oxaliplatin is a neoplastic drug used in metastatic colorectal cancer where fluropyrimidines therapy or alone chemotherapy have failed, also used along with fluropyrimidines.
|Composition :|| Each vial contains:
Each vial contains:
Oxaliplatin -------------------25mg, 50mg, 100mg
Water for injection -----------q.s.
|Indications :|| oxaliplatin used in combination with infusional 5-fluorouracil/leucovorin, is indicated for:
â¢ adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.
treatment of advanced colorectal cancer.
|Contraindications :|| Oxaliplatin should not be administered to patients with a history of known allergy to oxaliplatin or other platinum compounds .
|Adverse Effects :||Serious adverse reactions including anaphylaxis and allergic reactions, neuropathy,pulmonary toxicities and hepatotoxicities can occur..|
|Dosage :|| oxaliplatin 85 mg/mÂ² intravenous infusion in 250-500 mL 5% Dextrose injection, USP and leucovorin 200 mg/mÂ² intravenous infusion in 5% Dextrose Injection, USP both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-fluorouracil 400 mg/mÂ² intravenous bolus given over 2-4 minutes, followed by 5-fluorouracil 600 mg/mÂ² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.
Day 2: Leucovorin 200 mg/mÂ² intravenous infusion over 120 minutes, followed by 5-fluorouracil 400 mg/mÂ² intravenous bolus given over 2-4 minutes, followed by 5-fluorouracil 600 mg/mÂ² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.
|Pharmacological action :|| Oxaliplatin is a neoplastic drug used in metastatic colorectal cancer where fluropyrimidines therapy or alone chemotherapy have failed, also used along with fluropyrimidines.
Precautions : Oxaliplatin may rarely cause a severe (possibly fatal) allergic reaction within minutes after a dose. Tell your doctor immediately if you develop any signs of an allergic reaction (e.g., rash, itching, swelling, trouble breathing, dizziness)..
|Drug interaction:||No pharmacokinetic interaction between 85 mg/mÂ² of Oxaliplatin and infusional 5-fluorouracil has been observed in patients treated every 2 weeks, but increases of 5-fluorouracil plasma concentrations by approximately 20% have been observed with doses of 130 mg/mÂ² of Oxaliplatin administered every 3 weeks. In vitro, platinum was not displaced from plasma proteins by the following medications: erythromycin, salicylate, sodium valproate, granisetron, and paclitaxel. In vitro, oxaliplatin is not metabolized by, nor does it inhibit, human cytochrome P450 isoenzymes. No P450-mediated drug-drug interactions are therefore anticipated in patients..|
|Precautions:||Oxaliplatin may rarely cause a severe (possibly fatal) allergic reaction within minutes after a dose.|